Noise-Induced Breakdown of the Michaelis-Menten Equation in Steady-State Conditions
نویسندگان
چکیده
منابع مشابه
Noise-induced breakdown of the Michaelis-Menten equation in steady-state conditions.
The Michaelis-Menten (MM) equation is the basic equation of enzyme kinetics; it is also a basic building block of many models of biological systems. We build a stochastic and microscopic model of enzyme kinetics inside a small subcellular compartment. Using both theory and simulations, we show that intrinsic noise induces a breakdown of the MM equation even if steady-state metabolic conditions ...
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ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2009
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.102.218103